How to Clear Weeds from Interlocking Stone Pavers Permanently The absolute best way to clear weeds from interlocking stone pavers permanently is to pressure wash the joints completely, apply a targeted non-selective herbicide, and re-sand the entire surface using high-quality polymeric sand. Failing to lock down the joints between your stones with locking sand allows windblown seeds and rainwater to settle into the subbase, leading to recurring weed growth and cracked brick l